Chicken Bubble Biscuit Bake Casserole is a comforting and satisfying dish that brings together tender chicken, creamy sauce, and fluffy biscuits all in one warm casserole. It’s perfect for families or any gathering, providing a delicious and filling meal with minimal effort.
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Why make this recipe
This recipe is great for several reasons. First, it is quick and easy to prepare, making it ideal for busy weeknights. Second, it uses ingredients that are often already in your pantry or fridge. Plus, it’s a fun and tasty way to get in veggies while satisfying your cravings for comfort food. The bubbly goodness of this casserole makes it a hit with both kids and adults alike!
How to make Chicken Bubble Biscuit Bake Casserole
Ingredients:
- 2 cups cooked chicken (shredded or diced; rotisserie works great)
- 1 10.5 oz can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream (or plain Greek yogurt)
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper (to taste)
- 1 16 oz can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese (or mozzarella)
- 1 tbsp melted butter (optional, for brushing)
Directions:
- Preheat the oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish.
- Mix the filling: In a large bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until smooth.
- Add biscuits: Fold in the quartered biscuit pieces until they are well coated in the mixture.
- Assemble casserole: Pour everything into the prepared baking dish. Sprinkle the shredded cheese evenly over the top.
- Bake: Cover with foil and bake for 20 minutes. Remove the foil and bake for an additional 10-15 minutes, until the biscuits are puffed, golden, and cooked through.
- Finish: Brush with melted butter if desired. Let cool slightly before serving.

Chicken Bubble Biscuit Bake Casserole
A comforting casserole combining tender chicken, creamy sauce, and fluffy biscuits, perfect for families and gatherings.
- Total Time: 50 minutes
- Yield: 4 servings 1x
Ingredients
- 2 cups cooked chicken (shredded or diced; rotisserie works great)
- 1 10.5 oz can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream (or plain Greek yogurt)
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper (to taste)
- 1 16 oz can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese (or mozzarella)
- 1 tbsp melted butter (optional, for brushing)
Instructions
- Preheat the oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish.
- In a large bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until smooth.
- Fold in the quartered biscuit pieces until they are well coated in the mixture.
- Pour everything into the prepared baking dish. Sprinkle the shredded cheese evenly over the top.
- Cover with foil and bake for 20 minutes. Remove the foil and bake for an additional 10-15 minutes, until the biscuits are puffed, golden, and cooked through.
- Brush with melted butter if desired. Let cool slightly before serving.
Notes
For a quicker option, use pre-cooked store-bought chicken or a rotisserie chicken. Customize the mixed vegetables based on preferences.
- Prep Time: 15 minutes
- Cook Time: 35 minutes
- Category: Main Course
- Method: Baking
- Cuisine: American
- Diet: None
Nutrition
- Serving Size: 1 serving
- Calories: 400
- Sugar: 4g
- Sodium: 600mg
- Fat: 20g
- Saturated Fat: 9g
- Unsaturated Fat: 8g
- Trans Fat: 0g
- Carbohydrates: 35g
- Fiber: 3g
- Protein: 20g
- Cholesterol: 55mg
How to serve Chicken Bubble Biscuit Bake Casserole
Serve this casserole warm right out of the oven. It’s great on its own but pairs well with a simple side salad or some crusty bread. You can also garnish with fresh herbs like parsley for extra flavor and color.
How to store Chicken Bubble Biscuit Bake Casserole
Store any leftovers in an airtight container in the refrigerator. It keeps well for 3-4 days. For longer storage, you can freeze the casserole for up to 2 months. To reheat, thaw in the fridge overnight and then warm in the oven until heated through.
Tips to make Chicken Bubble Biscuit Bake Casserole
- For a quicker option, use pre-cooked store-bought chicken or a rotisserie chicken.
- Feel free to customize the mixed vegetables based on your family’s preferences or what you have on hand.
- If you want a little kick, add some hot sauce or crushed red pepper to the filling.
Variations
You can easily make this recipe vegetarian by using a meat substitute or simply omitting the chicken. You can also experiment with different cheeses like mozzarella or pepper jack for a different flavor profile.
FAQs
1. Can I use frozen chicken?
Yes, you can use frozen chicken; just make sure it’s fully cooked before adding it to the casserole.
2. What if I don’t have biscuit dough?
You can use homemade biscuit dough or even puff pastry as a substitute.
3. Is this recipe gluten-free?
To make it gluten-free, use gluten-free biscuit dough and ensure the other ingredients are certified gluten-free.
Conclusion
Chicken Bubble Biscuit Bake Casserole is a delightful dish that combines ease and flavor. Its warmth and comfort make it a perfect choice for dinner any night of the week. With simple ingredients and straightforward steps, you can create a meal that everyone will love. Enjoy this cozy casserole soon, and don’t forget to save some for leftovers!
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